Recently, a spotlight has been cast on research teams to be more culturally responsive and adaptive. However, few authors provide tangible ways to bring practices of cultural adaptation into the implementation of research and evaluation. Based on a systematic review of policies and procedures from a multi-site study with a less than 15% attrition rate over two years, we propose a promising model for embedding cultural adaptation in research studies. Researchers must recruit staff who are culturally responsive; convene for in-person trainings; establish a stratified supervision structure; shine light on cultural biases within study policies and procedures; and adapt the study based on feedback from culturally responsive staff. This paper offers practical strategies for studies to anticipate ways in which implementation can be designed to be more culturally responsive, as well as ways to support ongoing adaptation based on the needs of specific communities.